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Objevy Alexandra Fleminga
Život Alexandra Fleminga byl plný neuvěřitelných okolností, náhod, a objevů, díky kterým se stal posléze světoznámým, uznávaným mikrobiologem a bakteriologem. Jeho úspěšná vědecká kariéra započala už před První světovou válkou, ve které se vyznamenal na poli chirurgie, pokračovala v meziválečném období, ve kterém se uskutečnily jeho nejvýznamnější pokusy a byla zakončena ziskem Nobelovy ceny a pasováním do šlechtického stavu Sir.
Objevy v mládí
Jak už bylo zmíněno v úvodu, život Fleminga byl samá náhoda. Po ukončení lékařské fakulty byl vystudovaný chirurg, ale díky profesorům Wrightovi a Freemanovi, který si ho vybral pro jeho talent, ne v bakteriologii, ale ve střelbě, se stal mladý Alexandr součástí laboratoře, ve které působil celý život. První větší úspěch bylo stanovení prvotních příznaků tuberkulózy, čímž si laboratoř zajistila jméno a příjmy. Toto velice slibné období ukončila Světová válka.
První světová válka
Flemingovo jméno se během Světové války zviditelnilo opět díky profesoru Wrightovi. Wright byl nasazen v laboratoři, která působila na území Francie. S sebou si povolal i Freemana s Flemingem. Zde se projevil Fleming jako chirurg, když začal praktikovat odebírání poškozené tkáně, aby se zabránilo infekci nebo jejímu případnému šíření. Profesor Wright zde dokázal, že ke zničení mikrobů je třeba zavést do rány hypertonický roztok soli, který zvyšuje odtok lymfy z těla. Dalším významným počinem této laboratoře bylo zjištění, že prostředky, kterými se sterilizovali chirurgické nástroje, jsou nedostačují, ba dokonce napomáhají růstu a životu bakterií. Tyto poznatky byli důležité pro další rozvoj chirurgie.
Objev lysozymu
K tomuto objevu došlo v roce 1922. Fleming vzal nosní hlen a umístil ho do Petriho misky, ve které byli už předtím kolonie mikroorganismů, které následně uhynuly. To samé se stalo, když umístil do misky slzu. Proto se rozhodl zkoumat slzy a nalezl enzym, který pojmenoval lysozym. Během dalších pozorování zjistil, že lysozym nezabíjí všechny mikroorganismy, ale pouze ty neškodné. Ovšem Fleminga napadlo, že lysozym vlastně určuje, které mikroorganismy jsou patogenní. Bakterie povětšinou zabíjel lysozym obsažený ve vaječném bílku, který ovšem nikdo neuměl oddělit. Proto pokus probíhal aplikací ředěného bílku nitrožilně králíkovi. Pokusy byly úspěšné, ale příliš náročné na tehdejší dobu.
Lysozym (lysis-zředěný) je enzym, který se vyskytuje v lidském těle nebo vaječném bílku. Má silné antibakteriální účinky, které narušují buněčné stěny bakterií.
Objev penicilinu
Je známo, že největší objevy a vynálezy vznikly a vznikají náhodou. Ne jinak tomu bylo v roce 1928 kdy, se přepsala historie medicíny, aniž by to kdokoliv v té době věděl nebo snad jenom tušil. Alexander Fleming toho dne vešel do laboratoře, kde byla zapomenutá Petriho miska, ve které byl agar (živná směs z červených řas, ve které se pěstují mikroorganismy), na něm byla plíseň. A právě v tento okamžik objevil Fleming antibiotickou účinnost penicilinu, konkrétně to byla houba Penicillium notatu. Látky, které uvolňovala, zabíjely většinu bakterií, kromě těch, které způsobují tyfus. Tento jev byl sice už známý, ale nikomu se ho nepodařilo provést laboratorně s takovým úspěchem. Aby mohli i nadále pozorovat penicilin, pěstoval se v masovém vývaru o teplotě 37⁰C. Po poradě s mykology byla tato teplota snížena na 20⁰C. Vzniklý vývar opravdu fungoval, zabíjel škodlivé bakterie a neškodil fagocytům (buňka, která je schopná pohlcovat pevné částice skrz membránu). Tento produkt fungoval při zředění, ale vydržel jen krátkou dobu. Zásadní problémem bylo že, nikdo neuměl oddělit tuto látku a vývar jako takový byl v medicíně nepoužitelný. Ačkoliv Fleming svůj objev publikoval mezi ostatní vědce, nikdo nejevil o jeho objev zájem.
Vše se změnilo v roce 1940 chemikovi Ernstu Chainovi a biochemikovi Howardu Floreymu. Brzy se začalo s testováním na zvířatech, které bylo více než uspokojivé. V únoru 1941 byl poprvé podán lék člověku, který umíral. Pro nedostatek látky pacient zemřel, ale léčivá účinnost penicilinu byla prokázána i na lidech. Po dostatečném nashromáždění zásob, byl penicilin podán dalším třem lidem. Dva pacienti se úspěšně uzdravili, třetí zemřel na komplikace.
Naneštěstí pro Fleminga i společnost se tyto převratné objevy odehrály během Druhé světové války. Nikdo si nemohl dovolit zafinancovat výrobu léčiva, která by byla prodělečná. Proto se Florey rozhodl odjet do USA, kde se pokusili vypěstovat penicilin na kukuřici, ale to se nezdařilo. Jediným úspěchem byl plesnivý meloun, který se stal základem na výrobu penicilinu v USA a prvních deseti tisíců litrů. Z této kultury vznikly i všechny ostatních, na kterých se vyrábí penicilin dodnes. V roce 1942 se rozšířila zpráva o novém léku a o rok později už se o něj zajímali farmaceutické společnosti. Tento objev vynesl pánům Chainovi, Floreymu a Flemingovi Nobelu cenu, kterou obdrželi 25.10.1945.
Sir Alexander Fleming byl za svůj bohatý život ověnčen mnoha oceněními a zásluhami. On sám však sebe považoval vždy za člověka náhod. A jak už bylo mnohokrát řečeno, tohoto velikána medicíny doprovázela náhoda na každém kroku. A za to jsme vděčni.
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(Aaronpoera, 7. 9. 2023 11:46)
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당신의 casino's enthusiasm을 for 슬롯 site 회원가입 안내. How exactly 시작할지, main 단계 및 advice을 review. Slot machine site sign-up 안내로 더욱 enjoyably 시작해보세요.
Gambling 게임의 매력적인 세계로의 journey을 start, 슬롯 사이트 회원가입이 necessary입니다. "In this article, we will" "Slot platform registration 안내"에 대해 in detail 설명하고, key 단계 및 유용한 details를 provide. 당신의 카지노 passion을 현실로 만들어보세요!
Slot machine platform 회원가입 안내
Slot machine site 회원가입은 간단하면서도 fun procedure입니다. Here are 회원가입을 위한 sequential 안내입니다.
슬롯 site choice
The most initially 할 일은 what slot platform를 선택할지 결정하는 것입니다. Different 사이트가 있으며, 각 platform offers games types and 보너스가 다를 수 있습니다. 신뢰할 sites 있는 platform choose 보안과 ease 둘 secure 확보하세요.
Registration option press
선택한 Slot site's site 접속한 후, typically 화면 상단에 위치한 "registration" 또는 "join" button find 클릭합니다.
Details input
Registration portal you go, 필요한 정보를 enter해야 합니다. 주로 다음과 같은 정보가 needed.
아이디: for signing in use ID를 create.
Passcode: account's safety 위한 password를 create.
Personalized information: Name, 생년월일, 이메일 등의 personal 정보를 입력하세요.
Usage terms
대부분의 슬롯 platforms utilization terms and conditions privacy 처리 방침을 provide. These carefully 읽고 agree sign-up을 완료할 수 있습니다. Important points inquisitive 점이 있다면 고객 support contact.
Registration complete
필요한 information everything enter 이용 terms and conditions 동의한 후, "registration completed" 또는 "확인" button press 회원가입을 finish.
Main Tips 및 Cautions
Bonuses 및 Promo offers verify
Many 슬롯 sites 새로 가입한 회원에게 bonuses or 무료 스핀을 offer. 회원가입, 이러한 혜택을 check and 활용하세요.
Deposit and withdrawal methods 방법 familiarize with
Slot sites depositing 출금을 to various 방법을 제공합니다. 편리하게 이용할 options 있는 methods beforehand 알아두세요.
문제 해결을 위한 고객 support
During registration 중 또는 이후에 문제가 may occur 있습니다. 사이트의 고객 지원팀과 연락하여 assistance 받을 수 있습니다.
책임 있는 도박
슬롯 sign-up 후에는 whenever responsible 도박을 engage in 것이 중요합니다. Budget 설정하고 감정에 휩쓸리지 않도록 exercise caution.
자주 묻는 질문 (FAQs)
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Q: Are there any 별도의 fees가 있나요?
A: The majority of 슬롯 platforms 회원가입에 별도의 fees do not impose 않습니다.
Q: 어떤 ID should be submitted 하나요?
A: Generally, 주민등록증이나 운전면허증과 같은 정부 발급 신분증을 needs to be provided 합니다.
Q: When do use the bonus 언제 can be used 있나요?
A: 무료 bonus 회원가입 후 즉시 given 특정 conditions 충족한 후에 is eligible for use 있습니다.
Q: 여러 sites join 되나요?
A: 네, 여러 slot sites are allowed to join 다양한 gaming bonus enjoy 있습니다.
Q: Is my sign-up information 안전하게 보관되나요?
A: Trusted 수 있는 사이트는 member information securely safeguard. Personal information 보호 policy check.
Q: Can I play games without registering 게임을 할 수 있을까요?
A: Some sites 회원가입 없이도 데모 버전의 게임을 offer 합니다. 하지만 actual 베팅은 signing up is 필요합니다.
결론 "슬롯 sign-up 안내"를 통해 easily
safely 카지노 gaming begin 있는 방법을 배웠습니다. 신중하게 Slot sites 선택하고 회원가입을 완료하여 pleasant gaming adventure have fun.
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kantorbola
(RalphVox, 30. 9. 2023 23:24)