Discoveries
Objevy Alexandra Fleminga
Život Alexandra Fleminga byl plný neuvěřitelných okolností, náhod, a objevů, díky kterým se stal posléze světoznámým, uznávaným mikrobiologem a bakteriologem. Jeho úspěšná vědecká kariéra započala už před První světovou válkou, ve které se vyznamenal na poli chirurgie, pokračovala v meziválečném období, ve kterém se uskutečnily jeho nejvýznamnější pokusy a byla zakončena ziskem Nobelovy ceny a pasováním do šlechtického stavu Sir.
Objevy v mládí
Jak už bylo zmíněno v úvodu, život Fleminga byl samá náhoda. Po ukončení lékařské fakulty byl vystudovaný chirurg, ale díky profesorům Wrightovi a Freemanovi, který si ho vybral pro jeho talent, ne v bakteriologii, ale ve střelbě, se stal mladý Alexandr součástí laboratoře, ve které působil celý život. První větší úspěch bylo stanovení prvotních příznaků tuberkulózy, čímž si laboratoř zajistila jméno a příjmy. Toto velice slibné období ukončila Světová válka.
První světová válka
Flemingovo jméno se během Světové války zviditelnilo opět díky profesoru Wrightovi. Wright byl nasazen v laboratoři, která působila na území Francie. S sebou si povolal i Freemana s Flemingem. Zde se projevil Fleming jako chirurg, když začal praktikovat odebírání poškozené tkáně, aby se zabránilo infekci nebo jejímu případnému šíření. Profesor Wright zde dokázal, že ke zničení mikrobů je třeba zavést do rány hypertonický roztok soli, který zvyšuje odtok lymfy z těla. Dalším významným počinem této laboratoře bylo zjištění, že prostředky, kterými se sterilizovali chirurgické nástroje, jsou nedostačují, ba dokonce napomáhají růstu a životu bakterií. Tyto poznatky byli důležité pro další rozvoj chirurgie.
Objev lysozymu
K tomuto objevu došlo v roce 1922. Fleming vzal nosní hlen a umístil ho do Petriho misky, ve které byli už předtím kolonie mikroorganismů, které následně uhynuly. To samé se stalo, když umístil do misky slzu. Proto se rozhodl zkoumat slzy a nalezl enzym, který pojmenoval lysozym. Během dalších pozorování zjistil, že lysozym nezabíjí všechny mikroorganismy, ale pouze ty neškodné. Ovšem Fleminga napadlo, že lysozym vlastně určuje, které mikroorganismy jsou patogenní. Bakterie povětšinou zabíjel lysozym obsažený ve vaječném bílku, který ovšem nikdo neuměl oddělit. Proto pokus probíhal aplikací ředěného bílku nitrožilně králíkovi. Pokusy byly úspěšné, ale příliš náročné na tehdejší dobu.
Lysozym (lysis-zředěný) je enzym, který se vyskytuje v lidském těle nebo vaječném bílku. Má silné antibakteriální účinky, které narušují buněčné stěny bakterií.
Objev penicilinu
Je známo, že největší objevy a vynálezy vznikly a vznikají náhodou. Ne jinak tomu bylo v roce 1928 kdy, se přepsala historie medicíny, aniž by to kdokoliv v té době věděl nebo snad jenom tušil. Alexander Fleming toho dne vešel do laboratoře, kde byla zapomenutá Petriho miska, ve které byl agar (živná směs z červených řas, ve které se pěstují mikroorganismy), na něm byla plíseň. A právě v tento okamžik objevil Fleming antibiotickou účinnost penicilinu, konkrétně to byla houba Penicillium notatu. Látky, které uvolňovala, zabíjely většinu bakterií, kromě těch, které způsobují tyfus. Tento jev byl sice už známý, ale nikomu se ho nepodařilo provést laboratorně s takovým úspěchem. Aby mohli i nadále pozorovat penicilin, pěstoval se v masovém vývaru o teplotě 37⁰C. Po poradě s mykology byla tato teplota snížena na 20⁰C. Vzniklý vývar opravdu fungoval, zabíjel škodlivé bakterie a neškodil fagocytům (buňka, která je schopná pohlcovat pevné částice skrz membránu). Tento produkt fungoval při zředění, ale vydržel jen krátkou dobu. Zásadní problémem bylo že, nikdo neuměl oddělit tuto látku a vývar jako takový byl v medicíně nepoužitelný. Ačkoliv Fleming svůj objev publikoval mezi ostatní vědce, nikdo nejevil o jeho objev zájem.
Vše se změnilo v roce 1940 chemikovi Ernstu Chainovi a biochemikovi Howardu Floreymu. Brzy se začalo s testováním na zvířatech, které bylo více než uspokojivé. V únoru 1941 byl poprvé podán lék člověku, který umíral. Pro nedostatek látky pacient zemřel, ale léčivá účinnost penicilinu byla prokázána i na lidech. Po dostatečném nashromáždění zásob, byl penicilin podán dalším třem lidem. Dva pacienti se úspěšně uzdravili, třetí zemřel na komplikace.
Naneštěstí pro Fleminga i společnost se tyto převratné objevy odehrály během Druhé světové války. Nikdo si nemohl dovolit zafinancovat výrobu léčiva, která by byla prodělečná. Proto se Florey rozhodl odjet do USA, kde se pokusili vypěstovat penicilin na kukuřici, ale to se nezdařilo. Jediným úspěchem byl plesnivý meloun, který se stal základem na výrobu penicilinu v USA a prvních deseti tisíců litrů. Z této kultury vznikly i všechny ostatních, na kterých se vyrábí penicilin dodnes. V roce 1942 se rozšířila zpráva o novém léku a o rok později už se o něj zajímali farmaceutické společnosti. Tento objev vynesl pánům Chainovi, Floreymu a Flemingovi Nobelu cenu, kterou obdrželi 25.10.1945.
Sir Alexander Fleming byl za svůj bohatý život ověnčen mnoha oceněními a zásluhami. On sám však sebe považoval vždy za člověka náhod. A jak už bylo mnohokrát řečeno, tohoto velikána medicíny doprovázela náhoda na každém kroku. A za to jsme vděčni.
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Our team comprises seasoned professionals with a wealth of experience in diverse IT sectors. Trust us to provide remedies supported by proficiency that makes a dissimilarity.
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Your delight is our priority. Dean Hill Computer Assistance proceeds past service provision; we build permanent bonds by unparalleled buyer backing, securing your serenity of intellect.
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In an era where data is irreplaceable, security is non-negotiable. Chief Hill Digital Assistance deploys anticipatory measures to secure your technology assets, keeping possible dangers at distance.
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Embark on a trek of digital excellence alongside Chief Hill Digital Services. From resolving to optimization, we are your collaborators in success. Reach us currently and undergo the conversional power of superior IT remedies.
Unbinding Excellence in Tech Remedies: Dean Bradley Computer Services
(ThomasVaf, 5. 12. 2023 4:43)
Reveal Cutting-Edge IT Solutions with Chief Bradley Technology Services
In the fast-paced universe of technology, staying beforehand is not merely an asset; it's a imperative. Chief Bradley Computer Services arises as your lighthouse for avant-garde and trustworthy IT resolutions, securing your business cruises smoothly by the technology tides.
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Can be you tired of technology hassles disturbing your process? Chief Hill Technology Assistance presents matchless IT assistance, a cord for enterprises pursuing nonstop procedures. Our seasoned professionals are at your assistance, proficient at diagnosing and quickly settling matters to keep your structures at their prime.
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Personalized Remedies for Assorted Necessities
A sole dimension won't suit each in the energetic sphere of technology. Dean Hill Digital Services grasps this, providing tailored remedies accommodating to your distinct needs. From system enhancement to cybersecurity, our services are meticulously tailored to catapult your company forward.
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In the digital setting, framework is the backbone of success. Chief Hill Computer Services combines the most recent technologies into your design, guaranteeing your framework is no longer merely sturdy but additionally primed for forthcoming improvements. Continue beforehand in the tech rivalry alongside our sharp-edge solutions.
Why Pick Chief Bradley Technology Services?
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Our crew constitutes experienced experts with a fortune of undergoing in assorted IT sectors. Entrust us to render resolutions supported by expertise that renders a difference.
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Your fulfillment is our necessity. Dean Bradley Computer Services goes beyond assistance provision; we build permanent connections via peerless client assistance, guaranteeing your tranquility of mind.
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In an age where statistics is invaluable, safety is non-negotiable. Dean Bradley Computer Services deploys proactive evaluations to secure your digital assets, retaining possible jeopardies at distance.
Partner alongside Success, Select Dean Bradley Technology Services
Commence on a journey of technological excellence alongside Dean Bradley Computer Assistance. From diagnosing to enhancement, we are your partners in victory. Reach us today and experience the conversional strength of superior IT solutions.
Unbinding Excellence in Digital Solutions: Dean Bradley Computer Services
(ThomasVaf, 5. 12. 2023 1:40)
Discover Sharp-Edge IT Solutions with Chief Hill Technology Assistance
In the fast-paced world of technology, staying beforehand is no longer merely an advantage; it's a essential. Dean Bradley Digital Services arises as your beacon for avant-garde and reliable IT solutions, ensuring your company navigates fluidly via the digital tides.
Elevating Performance via Specialist IT Backing
Are you tired of technology difficulties interrupting your workflow? Dean Hill Technology Services provides peerless IT support, a cord for companies seeking nonstop processes. Our skilled experts are at your assistance, adept at resolving and quickly solving issues to retain your structures at their prime.
https://www.yelp.com/biz/dean-bradley-computer-services-oakland
Tailored Solutions for Varied Necessities
One magnitude does not fit each in the dynamic realm of expertise. Chief Bradley Technology Services grasps this, providing bespoke solutions accommodating to your singular requirements. From system refinement to data security, our services are meticulously customized to propel your enterprise forward.
Maximizing Efficiency alongside State-of-the-Fine art System
In the technology backdrop, framework is the backbone of success. Chief Bradley Computer Services combines the most recent technologies into your setup, ensuring your infrastructure is no longer simply sturdy however also prepared for prospective advancements. Stay beforehand in the technology rivalry with our cutting-edge solutions.
Why Select Dean Bradley Computer Assistance?
Expertise That Signifies
Our crew consists of experienced experts having a fortune of undergoing in varied IT sectors. Entrust us to supply resolutions backed by prowess that makes a dissimilarity.
Peerless Buyer Backing
Your delight is our priority. Dean Bradley Technology Services proceeds past assistance provision; we build lasting bonds via peerless customer assistance, guaranteeing your tranquility of mind.
Preventive Safety Assessments
In an time where statistics is irreplaceable, safety is un-negotiable. Dean Hill Technology Services implements preventive measures to secure your technology resources, retaining possible dangers at distance.
Partner accompanied by Success, Choose Chief Bradley Computer Services
Start on a voyage of digital excellence alongside Chief Bradley Digital Services. From resolving to enhancement, we are your partners in victory. Contact us currently and undergo the metamorphic might of superior IT resolutions.
Unleashing Excellence in Tech Resolutions: Dean Bradley Digital Assistance
(ThomasVaf, 5. 12. 2023 0:40)
Reveal Sharp-Edge IT Remedies with Chief Bradley Digital Assistance
In the fast-paced world of expertise, staying ahead is not simply an advantage; it's a necessity. Chief Hill Digital Assistance surfaces as your lighthouse for avant-garde and trustworthy IT resolutions, guaranteeing your company sails fluidly by the technology streams.
Enhancing Performance by Expert IT Assistance
Are you tired of digital hassles disrupting your progression? Dean Bradley Technology Assistance offers peerless IT support, a link for businesses seeking continuous operations. Our experienced professionals are at your assistance, proficient at diagnosing and quickly solving concerns to maintain your structures at their peak.
https://www.yelp.com/biz/dean-bradley-computer-services-oakland
Tailored Remedies for Varied Needs
One dimension won't accommodate each in the dynamic realm of technique. Dean Bradley Digital Services comprehends this, rendering bespoke resolutions fitting to your singular prerequisites. From network refinement to cybersecurity, our assistance are meticulously tailored to catapult your company forward.
Amplifying Capability accompanied by National-of-the-Art Framework
In the digital setting, infrastructure is the anchor of victory. Chief Bradley Computer Services assimilates the latest technologies into your configuration, guaranteeing your infrastructure is no longer simply robust but also prepared for forthcoming advancements. Remain ahead in the technology competition accompanied by our sharp-edge resolutions.
Why Select Dean Hill Computer Services?
Prowess That Signifies
Our squad consists of experienced specialists with a fortune of undergoing in diverse IT sectors. Trust us to render resolutions supported by prowess that renders a dissimilarity.
Unparalleled Client Backing
Your satisfaction is our imperative. Dean Bradley Computer Assistance goes over assistance rendering; we construct enduring relationships via matchless buyer support, ensuring your tranquility of intellect.
Anticipatory Defense Evaluations
In an age where figures is priceless, safety is non-negotiable. Chief Bradley Technology Assistance installs anticipatory evaluations to secure your digital resources, retaining prospective jeopardies at distance.
Cooperate accompanied by Victory, Select Dean Hill Computer Services
Commence on a voyage of technological superiority alongside Chief Hill Technology Services. From resolving to optimization, we are your collaborators in achievement. Reach us now and undergo the transformative might of superior IT solutions.
Unlocking Superiority in Digital Solutions: Dean Bradley Technology Services
(ThomasVaf, 4. 12. 2023 23:40)
Discover Sharp-Edge IT Resolutions accompanied by Dean Bradley Computer Assistance
In the fast-paced universe of technology, continuing ahead is no longer just an benefit; it's a essential. Dean Hill Digital Services surfaces as your spotlight for innovative and trustworthy IT resolutions, ensuring your business navigates smoothly through the technology streams.
Elevating Operation via Expert IT Assistance
Are you fatigued of technology difficulties disrupting your progression? Chief Bradley Technology Assistance provides peerless IT support, a link for enterprises chasing uninterrupted operations. Our seasoned experts are at your service, adept at troubleshooting and swiftly solving concerns to retain your frameworks at their zenith.
https://www.yelp.com/biz/dean-bradley-computer-services-oakland
Customized Remedies for Diverse Needs
A sole magnitude does not suit each in the dynamic domain of technique. Chief Hill Computer Assistance understands this, offering tailored remedies catering to your unique prerequisites. From network optimization to cybersecurity, our services are fastidiously personalized to catapult your company forward.
Maximizing Productivity alongside National-of-the-Art Framework
In the digital backdrop, infrastructure is the anchor of success. Dean Bradley Technology Assistance assimilates the most recent techniques into your setup, guaranteeing your infrastructure is no longer simply sturdy however also primed for future advancements. Continue beforehand in the digital rivalry accompanied by our sharp-edge resolutions.
Why Choose Chief Hill Technology Services?
Expertise That Signifies
Our crew consists of skilled specialists with a fortune of experience in diverse IT areas. Trust us to supply remedies backed by proficiency that makes a dissimilarity.
Peerless Client Assistance
Your satisfaction is our imperative. Chief Bradley Digital Services goes over assistance rendering; we fabricate lasting connections through peerless customer backing, ensuring your serenity of psyche.
Proactive Safety Measures
In an time where data is invaluable, safety is un-negotiable. Dean Hill Computer Services implements anticipatory measures to secure your digital valuables, retaining prospective threats at bay.
Cooperate with Success, Pick Chief Hill Technology Assistance
Commence on a trek of technological superiority accompanied by Dean Hill Computer Assistance. From troubleshooting to enhancement, we are your collaborators in achievement. Contact us today and endure the transformative might of superior IT resolutions.
Unleashing Superiority in Digital Remedies: Dean Hill Computer Services
(ThomasVaf, 4. 12. 2023 22:40)
Reveal Sharp-Edge IT Remedies with Chief Hill Computer Services
In the fast-paced universe of technology, staying ahead is not merely an benefit; it's a necessity. Chief Bradley Digital Assistance emerges as your spotlight for innovative and dependable IT remedies, securing your business navigates fluidly via the technology tides.
Boosting Performance through Specialist IT Backing
Are you exhausted of tech hassles interrupting your progression? Dean Hill Technology Services provides matchless IT assistance, a cord for companies seeking uninterrupted processes. Our seasoned experts are at your assistance, skilled at resolving and swiftly resolving issues to keep your systems at their zenith.
https://www.yelp.com/biz/dean-bradley-computer-services-oakland
Customized Resolutions for Assorted Necessities
A single magnitude does not suit each in the lively domain of technique. Dean Hill Computer Assistance grasps this, rendering customized solutions catering to your singular requirements. From network refinement to data security, our assistance are meticulously customized to catapult your business forward.
Amplifying Efficiency alongside State-of-the-Fine art Infrastructure
In the technology landscape, infrastructure is the anchor of victory. Chief Bradley Digital Services assimilates the newest expertise into your configuration, guaranteeing your framework is no longer just sturdy but additionally set for future advancements. Continue beforehand in the tech race with our cutting-edge solutions.
Why Choose Dean Hill Technology Assistance?
Prowess That Denotes
Our squad constitutes skilled professionals having a wealth of experience in assorted IT domains. Trust us to render remedies backed by expertise that causes a dissimilarity.
Peerless Customer Backing
Your satisfaction is our imperative. Dean Bradley Technology Assistance proceeds over assistance provision; we build permanent connections via peerless customer support, guaranteeing your peace of intellect.
Proactive Security Assessments
In an time where data is priceless, security is non-negotiable. Dean Bradley Computer Services deploys proactive assessments to protect your technology assets, keeping potential dangers at bay.
Partner with Success, Select Chief Bradley Computer Assistance
Embark on a voyage of technological superiority with Chief Bradley Computer Assistance. From diagnosing to optimization, we are your collaborators in victory. Contact us today and experience the transformative strength of superior IT remedies.
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Строители бригада
(DenGaw, 2. 7. 2025 20:41)